The competitive inhibition that these generate on the hepatic enzymatic system probably activates clopidogrel, thus causing a decrease in its effectiveness as an antithrombotic. Recently the interaction between proton pump inhibitors and clopidogrel has been widely brought to attention. It is a pro-drug that must be converted at hepatic level into its active form by the CYP2C19 isoenzyme. (2) Associate Profesor of Medicine, Gastroenterology Unit, Universidad Nacional de ColombiaĬlopidogrel, a thienopyridine, is an antiplatelet drug which currently represents the cornerstone for the treatment of acute coronary events. (1) Internal Medicine Resident, Universidad Nacional de Colombia Ingrid Martínez MD (1), Vivian Coy MD (1), William Otero MD (2) Proton pump inhibitors and clopidogrel: Evidence of a Pharmacological interaction of great clinical impact
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